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South End Pizza and Grill on Tremont Street operates a broad-menu pizza shop with two distinct approaches: a House Favorites section featuring straightforward options like cheese pizza and the Meat Lover's (pepperoni, sausage, hamburger, bacon, and ham), and an extensive Gourmet Pizza lineup that ranges from traditional Margherita to more adventurous combinations like the Motorino (shrimp Alfredo with roasted garlic and mushrooms) and the Chicken Broccoli Extravaganza (broccoli and grilled chicken on Alfredo sauce). The menu reflects an interest in both sauced and white pizza variations—several gourmet options skip red sauce entirely, using ranch, pesto, or Alfredo bases instead. Beyond pizza, the shop serves calzones, wings, chicken fingers, and salads including a Goat Cheese Salad with kalamata olives and roasted red peppers. They also run bundle deals pairing pizzas with sides and drinks, and offer slices by the piece.