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Groton House of Pizza occupies a 1990s-style storefront on Main Street, operating as a neighborhood pizza house with decades of local patronage. The menu centers on pizza with a crispy crust, grinders served on fresh-baked sub rolls (described as having a French bread-style texture), and a notable steak and cheese grinder available with customizable toppings. The operation also offers salads, wings, and sandwiches. Owner Fanis and staff are noted for remembering regulars and their orders. Dine-in, takeout, and evening delivery are available; the space is wheelchair accessible and offers free parking.